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Evidence is increasing that all addiction without exception is related to difficulties with the brain's reward center, especially the mesolimbic system. This section of the problem regulates reward responses in getting food and sex, along with nurturing infants and children. One of the most important neurotransmitters involved in reward responses, both when they malfunction and when they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the level of dopamine released in in reaction to a stimulus"(Bostwick & Bucci, 2008).

Using two separate drugs to lose weight can be very effective there are combinations before the FDA now awaiting approval. When dealing with fat loss and the individuals who go through it one should err to the side of caution and permit the FDA do its job and demand some study be done in order that the public knows the side effects and dangers of the medications before we drive them. Keep in mind that drug companies have been in business to generate money and that they would say anything to keep people on the medications.

Researchers found that participants taking this drug for a year, dropped excess weight within one month and have kept the load off throughout the 56 weeks with the study. Contrave is a combination of the drugs naltrexone and bupropion, which usually reflect a brand new trend of weight-loss drugs which are made up of many active ingredient, which might make them more efficient and safer.

Combo-pilling will be the newest fad or better yet the newest into the future under scrutiny and so it is just more publicly known in recent months, comb-pilling to lose weight has been around since the eighties. The biggest reason that by using a combination of pills is now popular will be the fact that by right now there aren't long term prescription weight loss supplements that have been approved by the FDA besides orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications however some of the combinations have been rejected or have yet to be authorized by the FDA.

Seizures really are a side effect with Contrave and really should not be taken in those with seizure disorders. The drug may also raise blood pressure levels and heartrate, and mustn't be used in individuals with a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise blood pressure and pulse rate and must 't be used in patients with uncontrolled high hypertension, and also by anyone with heart-related and cerebrovascular (circulation dysfunction impacting your brain) disease. Patients with a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes using a boxed warning to alert medical researchers and patients towards the increased likelihood of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for smoking cessation. naltrexone ed discount website .

Approving a drug using this type of many potentially lethal side effects is inconsistent with the mission statement of the FDA. The power from the drug manufacturing lobby is blatantly evident inside the approval of numerous drugs requiring 'post-marketing' studies which are clearly significant to overall drug safety inside US.