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Thromboembolic events associated with immunoglobulin treatment

2013-02-15 22:32:00 (читать в оригинале)

ObjectiveDue to an increasing number of reported thromboembolic events (TEE) after the administration of one intravenous immunoglobulin (IVIG) and one subcutaneous immunoglobulin (SCIG), pharmacovigilance and laboratory data were collected to analyse the root cause and assess the reporting frequency of TEEs for various IG products.MethodsPaul‐Ehrlich‐Institut retrospectively analysed 228 reports of TEEs associated with six different IG products and estimated annual TEE‐reporting rates based on worldwide sale figures over a period of 6 years (2006–2011). In addition, non‐activated partial thromboplastin time (NAPTT) testing was performed to capture pro‐coagulant potential of six IG products (four IVIG and two SCIG).ResultsFor three IVIGs, the drug‐related TEE‐reporting ra...







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