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Analysis of Compound Weighing Precision in Drug Discovery

2013-02-15 22:26:00 (читать в оригинале)

Early drug discovery laboratories often call for the precise weighing of 1- to 5-mg solids into 4- to 5-g glass vials. For the balance used in this study (Mettler Toledo XP205), the manufacturer rates its accuracy at ±0.01 mg over the working range of 1 mg to 220 g and its precision or repeatability at 0.015 mg for 10-g weights. The manufacturer ratings were confirmed using standard steel weights, but these calibrators do not well represent the weighing precision of drug compound. For example, when pre-taring a 4- to 5-g vial on the balance and then weighing 1- to 5-mg calibration weights, although no bias was observed, precision dropped appreciably. When measuring solid sample in the range of 1 to 5 mg, deviation of the measured weight from the actual (true) weight was even worse, ...







Pediatrician schedule:Ansonia, CT 18,514
Pediatrician schedule: Avon, CT 17,357
Pediatrician schedule: Berlin, CT 20,467
Pediatrician schedule: Bethel, CT 9,185
Pediatrician schedule: Bloomfield, CT 20,696
Pediatrician schedule: Branford, CT 29,014
Pediatrician schedule: Bridgeport, CT 137,298
Pediatrician schedule: Bristol, CT 61,027
Pediatrician schedule: Brookfield, CT 16,680
Pediatrician schedule: Brooklyn, CT 7,977
Pediatrician schedule: Burlington, CT 9,178
Pediatrician schedule: Canton, CT 10,125
Pediatrician schedule: Central Manchester 32,686
Pediatrician schedule: Cheshire Village 6,101
Pediatrician schedule: Cheshire, CT 29,142
Pediatrician schedule: Colchester, CT 15,685
Pediatrician schedule: Conning Towers-Nautilus Park 10,428
Pediatrician schedule: Coventry, CT 12,307
Pediatrician schedule: Cromwell, CT 13,669
Pediatrician schedule: Danbury, CT 79,743
Pediatrician schedule: Darien, CT 19,710
Pediatrician schedule: Derby, CT 12,385
Pediatrician schedule: East Haddam 8,941
Pediatrician schedule: East Hartford 50,480
Pediatrician schedule: East Haven, CT 28,825
Pediatrician schedule: East Lyme 19,203
Pediatrician schedule: East Windsor 11,041
Pediatrician schedule: Easton, CT 7,383
Pediatrician schedule: Ellington, CT 14,829
Pediatrician schedule: Enfield, CT 45,259
Pediatrician schedule: Essex, CT 6,810
Pediatrician schedule: Fairfield, CT 57,578
Pediatrician schedule: Farmington, CT 25,144
Pediatrician schedule: Glastonbury 33,353
Pediatrician schedule: Glastonbury Center 7,287
Pediatrician schedule: Granby, CT 11,220
Pediatrician schedule: Greenwich, CT 62,368
Pediatrician schedule: Griswold, CT 11,508
Pediatrician schedule: Groton, CT 9,365
Pediatrician schedule: Guilford, CT 22,469
Pediatrician schedule: Haddam 7,954
Pediatrician schedule: Hamden, CT 58,119
Pediatrician schedule: Hartford, CT 124,060
Pediatrician schedule: Hebron, CT 9,304
Pediatrician schedule: Kensington, CT 8,697
Pediatrician schedule: Killingly 17,828
Pediatrician schedule: Killingworth 6,522
Pediatrician schedule: Lebanon, CT 7,409
Pediatrician schedule: Ledyard, CT 15,172
Pediatrician schedule: Madison, CT 18,824



Does Empiric Therapy for Atypical Pathogens Improve Outcomes for Patients with CAP?
Mercury Systems Awarded $16.7M IDIQ Contract From Naval Research Laboratory
Biomechanical insights into the aetiology of infraspinatus syndrome
Intestinal microbiota in patients with non‐alcoholic fatty liver disease
Evidence-based consensus on the insertion of central venous access devices: definition of minimal requirements for training

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The use of Petri nets and a two-zone model for fire scene reconstruction - Muller A, Demouge F, Jeguirim M, Fromy P, Vantelon JP.

2013-02-15 22:26:00 (читать в оригинале)

Fire scene investigation relies on in situ investigation (observations that take place where the fire occurred) and laboratory analysis. Nowadays the role and place of fire modelling in fire forensic investigation are debated within the forensic community.... (Source: SafetyLit: All (Unduplicated))







Pediatrician schedule:Ansonia, CT 18,514
Pediatrician schedule: Avon, CT 17,357
Pediatrician schedule: Berlin, CT 20,467
Pediatrician schedule: Bethel, CT 9,185
Pediatrician schedule: Bloomfield, CT 20,696
Pediatrician schedule: Branford, CT 29,014
Pediatrician schedule: Bridgeport, CT 137,298
Pediatrician schedule: Bristol, CT 61,027
Pediatrician schedule: Brookfield, CT 16,680
Pediatrician schedule: Brooklyn, CT 7,977
Pediatrician schedule: Burlington, CT 9,178
Pediatrician schedule: Canton, CT 10,125
Pediatrician schedule: Central Manchester 32,686
Pediatrician schedule: Cheshire Village 6,101
Pediatrician schedule: Cheshire, CT 29,142
Pediatrician schedule: Colchester, CT 15,685
Pediatrician schedule: Conning Towers-Nautilus Park 10,428
Pediatrician schedule: Coventry, CT 12,307
Pediatrician schedule: Cromwell, CT 13,669
Pediatrician schedule: Danbury, CT 79,743
Pediatrician schedule: Darien, CT 19,710
Pediatrician schedule: Derby, CT 12,385
Pediatrician schedule: East Haddam 8,941
Pediatrician schedule: East Hartford 50,480
Pediatrician schedule: East Haven, CT 28,825
Pediatrician schedule: East Lyme 19,203
Pediatrician schedule: East Windsor 11,041
Pediatrician schedule: Easton, CT 7,383
Pediatrician schedule: Ellington, CT 14,829
Pediatrician schedule: Enfield, CT 45,259
Pediatrician schedule: Essex, CT 6,810
Pediatrician schedule: Fairfield, CT 57,578
Pediatrician schedule: Farmington, CT 25,144
Pediatrician schedule: Glastonbury 33,353
Pediatrician schedule: Glastonbury Center 7,287
Pediatrician schedule: Granby, CT 11,220
Pediatrician schedule: Greenwich, CT 62,368
Pediatrician schedule: Griswold, CT 11,508
Pediatrician schedule: Groton, CT 9,365
Pediatrician schedule: Guilford, CT 22,469
Pediatrician schedule: Haddam 7,954
Pediatrician schedule: Hamden, CT 58,119
Pediatrician schedule: Hartford, CT 124,060
Pediatrician schedule: Hebron, CT 9,304
Pediatrician schedule: Kensington, CT 8,697
Pediatrician schedule: Killingly 17,828
Pediatrician schedule: Killingworth 6,522
Pediatrician schedule: Lebanon, CT 7,409
Pediatrician schedule: Ledyard, CT 15,172
Pediatrician schedule: Madison, CT 18,824



Development of Integrated Clinical Abilities by Simulated Patient Assisted Problem-based Learning Tutolial.
Survival of myeloma patients following the introduction of thalidomide as a second‐line therapy: a retrospective study at a single New Zealand centre
Nonconvulsive seizures after subarachnoid hemorrhage: Multimodal detection and outcomes
Quality of spirometry in 5‐to‐8‐year‐old children
Does Empiric Therapy for Atypical Pathogens Improve Outcomes for Patients with CAP?

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Significance of Antibodies Against the Native Ribosomal P Protein Complex and Recombinant P0, P1, and P2 Proteins in the Diagnosis of Chinese Patients with Systemic Lupus Erythematosus

2013-02-15 22:26:00 (читать в оригинале)

ConclusionBased on these results, antibodies against ribosomal P proteins are important complementary parameters to anti‐dsDNA and anti‐Sm, and should be considered for inclusion in the classification criteria for SLE. The diagnostic value of anti‐Rib‐P0/P1/P2 is diagnostically superior to that of anti‐Rib‐PC. (Source: Journal of Clinical Laboratory Analysis)







Pediatrician schedule:Ansonia, CT 18,514
Pediatrician schedule: Avon, CT 17,357
Pediatrician schedule: Berlin, CT 20,467
Pediatrician schedule: Bethel, CT 9,185
Pediatrician schedule: Bloomfield, CT 20,696
Pediatrician schedule: Branford, CT 29,014
Pediatrician schedule: Bridgeport, CT 137,298
Pediatrician schedule: Bristol, CT 61,027
Pediatrician schedule: Brookfield, CT 16,680
Pediatrician schedule: Brooklyn, CT 7,977
Pediatrician schedule: Burlington, CT 9,178
Pediatrician schedule: Canton, CT 10,125
Pediatrician schedule: Central Manchester 32,686
Pediatrician schedule: Cheshire Village 6,101
Pediatrician schedule: Cheshire, CT 29,142
Pediatrician schedule: Colchester, CT 15,685
Pediatrician schedule: Conning Towers-Nautilus Park 10,428
Pediatrician schedule: Coventry, CT 12,307
Pediatrician schedule: Cromwell, CT 13,669
Pediatrician schedule: Danbury, CT 79,743
Pediatrician schedule: Darien, CT 19,710
Pediatrician schedule: Derby, CT 12,385
Pediatrician schedule: East Haddam 8,941
Pediatrician schedule: East Hartford 50,480
Pediatrician schedule: East Haven, CT 28,825
Pediatrician schedule: East Lyme 19,203
Pediatrician schedule: East Windsor 11,041
Pediatrician schedule: Easton, CT 7,383
Pediatrician schedule: Ellington, CT 14,829
Pediatrician schedule: Enfield, CT 45,259
Pediatrician schedule: Essex, CT 6,810
Pediatrician schedule: Fairfield, CT 57,578
Pediatrician schedule: Farmington, CT 25,144
Pediatrician schedule: Glastonbury 33,353
Pediatrician schedule: Glastonbury Center 7,287
Pediatrician schedule: Granby, CT 11,220
Pediatrician schedule: Greenwich, CT 62,368
Pediatrician schedule: Griswold, CT 11,508
Pediatrician schedule: Groton, CT 9,365
Pediatrician schedule: Guilford, CT 22,469
Pediatrician schedule: Haddam 7,954
Pediatrician schedule: Hamden, CT 58,119
Pediatrician schedule: Hartford, CT 124,060
Pediatrician schedule: Hebron, CT 9,304
Pediatrician schedule: Kensington, CT 8,697
Pediatrician schedule: Killingly 17,828
Pediatrician schedule: Killingworth 6,522
Pediatrician schedule: Lebanon, CT 7,409
Pediatrician schedule: Ledyard, CT 15,172
Pediatrician schedule: Madison, CT 18,824



Biological sensitivity to context in couples: Why partner aggression hurts some more than others - Lorber MF, Erlanger AC, Slep AM.
Exfoliative erythroderma in an 80-year-old man
New Molecular Inhibitors Successfully Hit Difficult Cancer Target
Quality of spirometry in 5‐to‐8‐year‐old children
Upcoming Biology Education Conferences

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New Sepsis Management Standards for New York Hospitals Will Put Greater Emphasis on Use of Clinical Laboratory Tests for Diagnosis and Treatment

2013-02-15 22:26:00 (читать в оригинале)

There will be more focused lab testing and public reporting of sepsis results as New York State addresses growing problem following death of 12-year-old boy. New York State will implement tougher standards for the diagnosis and treatment of sepsis in hospitals. One consequence is expected to be more medical laboratory testing for patients suspected of [...] (Source: Dark Daily)







Pediatrician schedule:Ansonia, CT 18,514
Pediatrician schedule: Avon, CT 17,357
Pediatrician schedule: Berlin, CT 20,467
Pediatrician schedule: Bethel, CT 9,185
Pediatrician schedule: Bloomfield, CT 20,696
Pediatrician schedule: Branford, CT 29,014
Pediatrician schedule: Bridgeport, CT 137,298
Pediatrician schedule: Bristol, CT 61,027
Pediatrician schedule: Brookfield, CT 16,680
Pediatrician schedule: Brooklyn, CT 7,977
Pediatrician schedule: Burlington, CT 9,178
Pediatrician schedule: Canton, CT 10,125
Pediatrician schedule: Central Manchester 32,686
Pediatrician schedule: Cheshire Village 6,101
Pediatrician schedule: Cheshire, CT 29,142
Pediatrician schedule: Colchester, CT 15,685
Pediatrician schedule: Conning Towers-Nautilus Park 10,428
Pediatrician schedule: Coventry, CT 12,307
Pediatrician schedule: Cromwell, CT 13,669
Pediatrician schedule: Danbury, CT 79,743
Pediatrician schedule: Darien, CT 19,710
Pediatrician schedule: Derby, CT 12,385
Pediatrician schedule: East Haddam 8,941
Pediatrician schedule: East Hartford 50,480
Pediatrician schedule: East Haven, CT 28,825
Pediatrician schedule: East Lyme 19,203
Pediatrician schedule: East Windsor 11,041
Pediatrician schedule: Easton, CT 7,383
Pediatrician schedule: Ellington, CT 14,829
Pediatrician schedule: Enfield, CT 45,259
Pediatrician schedule: Essex, CT 6,810
Pediatrician schedule: Fairfield, CT 57,578
Pediatrician schedule: Farmington, CT 25,144
Pediatrician schedule: Glastonbury 33,353
Pediatrician schedule: Glastonbury Center 7,287
Pediatrician schedule: Granby, CT 11,220
Pediatrician schedule: Greenwich, CT 62,368
Pediatrician schedule: Griswold, CT 11,508
Pediatrician schedule: Groton, CT 9,365
Pediatrician schedule: Guilford, CT 22,469
Pediatrician schedule: Haddam 7,954
Pediatrician schedule: Hamden, CT 58,119
Pediatrician schedule: Hartford, CT 124,060
Pediatrician schedule: Hebron, CT 9,304
Pediatrician schedule: Kensington, CT 8,697
Pediatrician schedule: Killingly 17,828
Pediatrician schedule: Killingworth 6,522
Pediatrician schedule: Lebanon, CT 7,409
Pediatrician schedule: Ledyard, CT 15,172
Pediatrician schedule: Madison, CT 18,824



The use of Petri nets and a two-zone model for fire scene reconstruction - Muller A, Demouge F, Jeguirim M, Fromy P, Vantelon JP.
Does Empiric Therapy for Atypical Pathogens Improve Outcomes for Patients with CAP?
Exfoliative erythroderma in an 80-year-old man
Clues to chromosome crossovers
CSHL scientists identify a new strategy for interfering with a potent cancer-causing gene

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Mozambique: Cholera Confirmed in Northern Mozambique

2013-02-15 22:26:00 (читать в оригинале)

[IRIN]Johannesburg -In the last 10 days, 22 cases of the waterborne disease cholera have been confirmed by laboratory testing in three areas in and around the northern Mozambique town of Pemba, in Cabo Delgado Province. (Source: AllAfrica News: Health and Medicine)







Pediatrician schedule:Ansonia, CT 18,514
Pediatrician schedule: Avon, CT 17,357
Pediatrician schedule: Berlin, CT 20,467
Pediatrician schedule: Bethel, CT 9,185
Pediatrician schedule: Bloomfield, CT 20,696
Pediatrician schedule: Branford, CT 29,014
Pediatrician schedule: Bridgeport, CT 137,298
Pediatrician schedule: Bristol, CT 61,027
Pediatrician schedule: Brookfield, CT 16,680
Pediatrician schedule: Brooklyn, CT 7,977
Pediatrician schedule: Burlington, CT 9,178
Pediatrician schedule: Canton, CT 10,125
Pediatrician schedule: Central Manchester 32,686
Pediatrician schedule: Cheshire Village 6,101
Pediatrician schedule: Cheshire, CT 29,142
Pediatrician schedule: Colchester, CT 15,685
Pediatrician schedule: Conning Towers-Nautilus Park 10,428
Pediatrician schedule: Coventry, CT 12,307
Pediatrician schedule: Cromwell, CT 13,669
Pediatrician schedule: Danbury, CT 79,743
Pediatrician schedule: Darien, CT 19,710
Pediatrician schedule: Derby, CT 12,385
Pediatrician schedule: East Haddam 8,941
Pediatrician schedule: East Hartford 50,480
Pediatrician schedule: East Haven, CT 28,825
Pediatrician schedule: East Lyme 19,203
Pediatrician schedule: East Windsor 11,041
Pediatrician schedule: Easton, CT 7,383
Pediatrician schedule: Ellington, CT 14,829
Pediatrician schedule: Enfield, CT 45,259
Pediatrician schedule: Essex, CT 6,810
Pediatrician schedule: Fairfield, CT 57,578
Pediatrician schedule: Farmington, CT 25,144
Pediatrician schedule: Glastonbury 33,353
Pediatrician schedule: Glastonbury Center 7,287
Pediatrician schedule: Granby, CT 11,220
Pediatrician schedule: Greenwich, CT 62,368
Pediatrician schedule: Griswold, CT 11,508
Pediatrician schedule: Groton, CT 9,365
Pediatrician schedule: Guilford, CT 22,469
Pediatrician schedule: Haddam 7,954
Pediatrician schedule: Hamden, CT 58,119
Pediatrician schedule: Hartford, CT 124,060
Pediatrician schedule: Hebron, CT 9,304
Pediatrician schedule: Kensington, CT 8,697
Pediatrician schedule: Killingly 17,828
Pediatrician schedule: Killingworth 6,522
Pediatrician schedule: Lebanon, CT 7,409
Pediatrician schedule: Ledyard, CT 15,172
Pediatrician schedule: Madison, CT 18,824



Clues to chromosome crossovers
Biomechanical insights into the aetiology of infraspinatus syndrome
Years of fun in the sun mean big business for local lab
Evidence-based consensus on the insertion of central venous access devices: definition of minimal requirements for training
Quality of spirometry in 5‐to‐8‐year‐old children