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Comparison of the pharmacological profiles of murine antisense oligonucleotides targeting apolipoprotein B and microsomal triglyceride transfer protein [Research Articles]

2013-02-15 22:44:00 (читать в оригинале)

Therapeutic agents that suppress apolipoprotein B (apoB) and microsomal triglyceride transfer protein (MTP) levels/activity are being developed in the clinic to benefit patients who are unable to reach target LDL-C levels with maximally tolerated lipid-lowering drugs. To compare and contrast the metabolic consequences of reducing these targets, murine-specific apoB or MTP antisense oligonucleotides (ASOs) were administered to chow-fed and high fat-fed C57BL/6 or to chow-fed and Western diet-fed LDLr–/– mice for periods ranging from 2 to 12 weeks, and detailed analyses of various factors affecting fatty acid metabolism were performed. Administration of these drugs significantly reduced target hepatic mRNA and protein, leading to similar reductions in hepatic VLDL/triglyceride se...







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Pediatrician schedule: Boynton Beach 69,654
Pediatrician schedule: Bradenton 53,973
Pediatrician schedule: Brandon, FL 90,833
Pediatrician schedule: Brent, FL 22,845
Pediatrician schedule: Broadview Park 7,278
Pediatrician schedule: Brooksville, FL 8,267
Pediatrician schedule: Brownsville, FL 15,634
Pediatrician schedule: Butler Beach 6,265
Pediatrician schedule: Callaway, FL 13,972
Pediatrician schedule: Cantonment 44,893
Pediatrician schedule: Cape Canaveral 10,081
Pediatrician schedule: Cape Coral, FL 154,202
Pediatrician schedule: Carol City 64,569
Pediatrician schedule: Casselberry 24,792
Pediatrician schedule: Central Pasco 69,995
Pediatrician schedule: Central Volusia 24,310
Pediatrician schedule: Century Village 8,483
Pediatrician schedule: Cheval 8,864
Pediatrician schedule: Citrus Park 23,585
Pediatrician schedule: Citrus Park-Fern Lake, FL 117,103
Pediatrician schedule: Citrus Ridge 14,195
Pediatrician schedule: Clearwater, FL 106,081
Pediatrician schedule: Clermont, FL 13,252
Pediatrician schedule: Clewiston 7,107
Pediatrician schedule: Cocoa 16,538
Pediatrician schedule: Cocoa Beach 11,862
Pediatrician schedule: Cocoa West 7,806
Pediatrician schedule: Coconut Creek 50,544
Pediatrician schedule: Collier Manor-Cresthaven 8,287
Pediatrician schedule: Combee Settlement 6,422
Pediatrician schedule: Conway, FL 16,998
Pediatrician schedule: Cooper City 29,585
Pediatrician schedule: Coral Gables 44,425
Pediatrician schedule: Coral Springs, FL 126,518
Pediatrician schedule: Coral Terrace 26,482
Pediatrician schedule: Country Club, FL 39,441
Pediatrician schedule: Country Walk 11,571
Pediatrician schedule: Crestview, FL 19,868
Pediatrician schedule: Cutler Ridge 26,918
Pediatrician schedule: Cutler, FL 18,889
Pediatrician schedule: Cypress Gardens 10,449
Pediatrician schedule: Cypress Lake 15,915
Pediatrician schedule: Dade City 7,190
Pediatrician schedule: Dania Beach 21,477
Pediatrician schedule: Davie 91,729
Pediatrician schedule: Daytona Beach 63,795
Pediatrician schedule: De Bary 16,200


Effect of talc and water addition on olive oil quality and antioxidants
Differential effects of estrogen/androgen on the prevention of nonalcoholic fatty liver disease in the male rat [Research Articles]
Bone marrow NR4A expression is not a dominant factor in the development of atherosclerosis or macrophage polarization in mice [Research Articles]
Risk factors for cardiovascular disease: renewed interest in triglycerides
Eur. J. Lipid Sci. Technol. 1/2013
The efficacy and safety of ezetimibe coadministered with statin therapy in various patient groups
Fasting regulates FSP27 expression in the liver [Commentary]
Novel common and rare genetic determinants of paraoxonase activity: FTO, SERPINA12, and ITGAL [Patient-Oriented and Epidemiological Research]
Eur. J. Lipid Sci. Technol. 2/2013
Association of Shiga toxin glycosphingolipid receptors with membrane microdomains of toxin-sensitive lymphoid and myeloid cells [Research Articles]

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Influence of harvest year and cultivar on wax composition of olive oils

2013-02-15 22:44:00 (читать в оригинале)

AbstractOlive oils extracted from Italian cultivars in Calabria Region, Southern Italy were analyzed for their wax ester composition, for three successive harvest years. Three autochthonous cultivars from Calabria: Cassanese, Ottobratica and Sinopolese and seven allochtonous cultivars: Coratina, Itrana, Leccino, Nocellara Messinese, Nociara, Pendolino and Picholine were considered. This work demonstrates the presence of significant differences (ANOVA) for the different wax ester compounds present in these olive oils, taking into consideration the cultivar and the harvest year. The studied olive oils present a good wax ester composition according to both EU and IOC regulations. The cultivar Ottobratica showed the highest wax ester content, whereas Itrana presented the lowest content.Pract...







Pediatrician schedule: Boca Raton 83,280
Pediatrician schedule: Bonita Springs 42,874
Pediatrician schedule: Boyette 6,874
Pediatrician schedule: Boynton Beach 69,654
Pediatrician schedule: Bradenton 53,973
Pediatrician schedule: Brandon, FL 90,833
Pediatrician schedule: Brent, FL 22,845
Pediatrician schedule: Broadview Park 7,278
Pediatrician schedule: Brooksville, FL 8,267
Pediatrician schedule: Brownsville, FL 15,634
Pediatrician schedule: Butler Beach 6,265
Pediatrician schedule: Callaway, FL 13,972
Pediatrician schedule: Cantonment 44,893
Pediatrician schedule: Cape Canaveral 10,081
Pediatrician schedule: Cape Coral, FL 154,202
Pediatrician schedule: Carol City 64,569
Pediatrician schedule: Casselberry 24,792
Pediatrician schedule: Central Pasco 69,995
Pediatrician schedule: Central Volusia 24,310
Pediatrician schedule: Century Village 8,483
Pediatrician schedule: Cheval 8,864
Pediatrician schedule: Citrus Park 23,585
Pediatrician schedule: Citrus Park-Fern Lake, FL 117,103
Pediatrician schedule: Citrus Ridge 14,195
Pediatrician schedule: Clearwater, FL 106,081
Pediatrician schedule: Clermont, FL 13,252
Pediatrician schedule: Clewiston 7,107
Pediatrician schedule: Cocoa 16,538
Pediatrician schedule: Cocoa Beach 11,862
Pediatrician schedule: Cocoa West 7,806
Pediatrician schedule: Coconut Creek 50,544
Pediatrician schedule: Collier Manor-Cresthaven 8,287
Pediatrician schedule: Combee Settlement 6,422
Pediatrician schedule: Conway, FL 16,998
Pediatrician schedule: Cooper City 29,585
Pediatrician schedule: Coral Gables 44,425
Pediatrician schedule: Coral Springs, FL 126,518
Pediatrician schedule: Coral Terrace 26,482
Pediatrician schedule: Country Club, FL 39,441
Pediatrician schedule: Country Walk 11,571
Pediatrician schedule: Crestview, FL 19,868
Pediatrician schedule: Cutler Ridge 26,918
Pediatrician schedule: Cutler, FL 18,889
Pediatrician schedule: Cypress Gardens 10,449
Pediatrician schedule: Cypress Lake 15,915
Pediatrician schedule: Dade City 7,190
Pediatrician schedule: Dania Beach 21,477
Pediatrician schedule: Davie 91,729
Pediatrician schedule: Daytona Beach 63,795
Pediatrician schedule: De Bary 16,200


Diacylglycerol kinase inhibitor R59022 attenuates conjugated linoleic acid-mediated inflammation in human adipocytes [Research Articles]
Invariant NKT cell serves as a novel therapeutic target for control of obesity
Risk factors for cardiovascular disease: renewed interest in triglycerides
LCAT deficiency in mice is associated with a diminished adrenal glucocorticoid function [Research Articles]
Lipoprotein metabolism in patients with type 1 diabetes under intensive insulin treatment
Visualizing a multidrug resistance protein, EmrE, with major bacterial lipids using Brewster angle microscopy.
Probing microscopic material properties inside simulated membranes through spatially resolved three-dimensional local pressure fields and surface tensions.
The combined effects of genetic variation in the SIRT1 gene and dietary intake of n-3 and n-6 polyunsaturated fatty acids on serum LDL-C and HDL-C levels: a population based study
Monotopic topology is required for lipid droplet targeting of ancient ubiquitous protein 1 [Research Articles]
Enzymatic hydrolysis of palm stearin to produce diacylglycerol with a highly thermostable lipase

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ERRATA [Errata]

2013-02-15 22:44:00 (читать в оригинале)

(Source: The Journal of Lipid Research)







Pediatrician schedule: Boca Raton 83,280
Pediatrician schedule: Bonita Springs 42,874
Pediatrician schedule: Boyette 6,874
Pediatrician schedule: Boynton Beach 69,654
Pediatrician schedule: Bradenton 53,973
Pediatrician schedule: Brandon, FL 90,833
Pediatrician schedule: Brent, FL 22,845
Pediatrician schedule: Broadview Park 7,278
Pediatrician schedule: Brooksville, FL 8,267
Pediatrician schedule: Brownsville, FL 15,634
Pediatrician schedule: Butler Beach 6,265
Pediatrician schedule: Callaway, FL 13,972
Pediatrician schedule: Cantonment 44,893
Pediatrician schedule: Cape Canaveral 10,081
Pediatrician schedule: Cape Coral, FL 154,202
Pediatrician schedule: Carol City 64,569
Pediatrician schedule: Casselberry 24,792
Pediatrician schedule: Central Pasco 69,995
Pediatrician schedule: Central Volusia 24,310
Pediatrician schedule: Century Village 8,483
Pediatrician schedule: Cheval 8,864
Pediatrician schedule: Citrus Park 23,585
Pediatrician schedule: Citrus Park-Fern Lake, FL 117,103
Pediatrician schedule: Citrus Ridge 14,195
Pediatrician schedule: Clearwater, FL 106,081
Pediatrician schedule: Clermont, FL 13,252
Pediatrician schedule: Clewiston 7,107
Pediatrician schedule: Cocoa 16,538
Pediatrician schedule: Cocoa Beach 11,862
Pediatrician schedule: Cocoa West 7,806
Pediatrician schedule: Coconut Creek 50,544
Pediatrician schedule: Collier Manor-Cresthaven 8,287
Pediatrician schedule: Combee Settlement 6,422
Pediatrician schedule: Conway, FL 16,998
Pediatrician schedule: Cooper City 29,585
Pediatrician schedule: Coral Gables 44,425
Pediatrician schedule: Coral Springs, FL 126,518
Pediatrician schedule: Coral Terrace 26,482
Pediatrician schedule: Country Club, FL 39,441
Pediatrician schedule: Country Walk 11,571
Pediatrician schedule: Crestview, FL 19,868
Pediatrician schedule: Cutler Ridge 26,918
Pediatrician schedule: Cutler, FL 18,889
Pediatrician schedule: Cypress Gardens 10,449
Pediatrician schedule: Cypress Lake 15,915
Pediatrician schedule: Dade City 7,190
Pediatrician schedule: Dania Beach 21,477
Pediatrician schedule: Davie 91,729
Pediatrician schedule: Daytona Beach 63,795
Pediatrician schedule: De Bary 16,200


Probing microscopic material properties inside simulated membranes through spatially resolved three-dimensional local pressure fields and surface tensions.
Diacylglycerol kinase inhibitor R59022 attenuates conjugated linoleic acid-mediated inflammation in human adipocytes [Research Articles]
The combined effects of genetic variation in the SIRT1 gene and dietary intake of n-3 and n-6 polyunsaturated fatty acids on serum LDL-C and HDL-C levels: a population based study
Enzymatic hydrolysis of palm stearin to produce diacylglycerol with a highly thermostable lipase
Lipid–Protein Interactions in Membranes: implications for health and disease
Cobalt carbonyl complexes as probes for alkyne-tagged lipids [Methods]
Lipid metabolism, immunity and metabolic diseases
Cancer biomarkers and mass spectrometry-based analyses of phospholipids in body fluids
Influence of harvest year and cultivar on wax composition of olive oils
Caspase-1 deficiency in mice reduces intestinal triglyceride absorption and hepatic triglyceride secretion [Research Articles]

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The galactolipase activity of some microbial lipases and pancreatic enzymes

2013-02-15 22:44:00 (читать в оригинале)

AbstractSeveral well known microbial lipases were screened for their ability to hydrolyze synthetic medium chain monogalactosyldiacylglycerol (MGDG) and digalactosyldiacylglycerol (DGDG). Fusarium solani cutinase and Thermomyces lanuginosus lipase (TLL) were found to hydrolyze MGDG at high rates (984 ± 62 U/mg and 450 ± 41 U/mg, respectively). These activities remained however lower than those measured with pancreatic lipase‐related protein 2 (PLRP2) on the same substrate. As previously observed with PLRP2, galactolipid‐bile salt mixed micelles were found to be the best substrate form for microbial enzymes. The galactolipid to bile salt molar ratios for measuring maximum galactolipase activities were found to be similar to those previously established with PLRP2, suggesting that bil...







Pediatrician schedule: Boca Raton 83,280
Pediatrician schedule: Bonita Springs 42,874
Pediatrician schedule: Boyette 6,874
Pediatrician schedule: Boynton Beach 69,654
Pediatrician schedule: Bradenton 53,973
Pediatrician schedule: Brandon, FL 90,833
Pediatrician schedule: Brent, FL 22,845
Pediatrician schedule: Broadview Park 7,278
Pediatrician schedule: Brooksville, FL 8,267
Pediatrician schedule: Brownsville, FL 15,634
Pediatrician schedule: Butler Beach 6,265
Pediatrician schedule: Callaway, FL 13,972
Pediatrician schedule: Cantonment 44,893
Pediatrician schedule: Cape Canaveral 10,081
Pediatrician schedule: Cape Coral, FL 154,202
Pediatrician schedule: Carol City 64,569
Pediatrician schedule: Casselberry 24,792
Pediatrician schedule: Central Pasco 69,995
Pediatrician schedule: Central Volusia 24,310
Pediatrician schedule: Century Village 8,483
Pediatrician schedule: Cheval 8,864
Pediatrician schedule: Citrus Park 23,585
Pediatrician schedule: Citrus Park-Fern Lake, FL 117,103
Pediatrician schedule: Citrus Ridge 14,195
Pediatrician schedule: Clearwater, FL 106,081
Pediatrician schedule: Clermont, FL 13,252
Pediatrician schedule: Clewiston 7,107
Pediatrician schedule: Cocoa 16,538
Pediatrician schedule: Cocoa Beach 11,862
Pediatrician schedule: Cocoa West 7,806
Pediatrician schedule: Coconut Creek 50,544
Pediatrician schedule: Collier Manor-Cresthaven 8,287
Pediatrician schedule: Combee Settlement 6,422
Pediatrician schedule: Conway, FL 16,998
Pediatrician schedule: Cooper City 29,585
Pediatrician schedule: Coral Gables 44,425
Pediatrician schedule: Coral Springs, FL 126,518
Pediatrician schedule: Coral Terrace 26,482
Pediatrician schedule: Country Club, FL 39,441
Pediatrician schedule: Country Walk 11,571
Pediatrician schedule: Crestview, FL 19,868
Pediatrician schedule: Cutler Ridge 26,918
Pediatrician schedule: Cutler, FL 18,889
Pediatrician schedule: Cypress Gardens 10,449
Pediatrician schedule: Cypress Lake 15,915
Pediatrician schedule: Dade City 7,190
Pediatrician schedule: Dania Beach 21,477
Pediatrician schedule: Davie 91,729
Pediatrician schedule: Daytona Beach 63,795
Pediatrician schedule: De Bary 16,200


Adipose tissue arachidonic acid content is associated with the expression of 5-lipoxygenase in atherosclerotic plaques
Influence of oil phase concentration on droplet size distribution and stability of oil‐in‐water emulsions
The shape and free energy of a lipid bilayer surrounding a membrane inclusion.
LCAT deficiency in mice is associated with a diminished adrenal glucocorticoid function [Research Articles]
Non-HDL cholesterol, ApoB and LDL particle concentration in coronary heart disease risk prediction and treatment
Eur. J. Lipid Sci. Technol. 1/2013
Diacylglycerol kinase inhibitor R59022 attenuates conjugated linoleic acid-mediated inflammation in human adipocytes [Research Articles]
Comparison of the pharmacological profiles of murine antisense oligonucleotides targeting apolipoprotein B and microsomal triglyceride transfer protein [Research Articles]
Monotopic topology is required for lipid droplet targeting of ancient ubiquitous protein 1 [Research Articles]
Impact of extruded flaxseed meal supplemented diet on growth performance, oxidative stability and quality of broiler meat and meat products

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For Irrfan, it was all about becoming famous

2013-02-12 13:23:00 (читать в оригинале)


For Irrfan, it was all about becoming famous


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