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Probing microscopic material properties inside simulated membranes through spatially resolved three-dimensional local pressure fields and surface tensions.

2013-02-15 22:39:00 (читать в оригинале)

We present a means to calculate pressure and surface tension in a 3D-resolved manner within molecular-dynamics simulations and show how such measurements can yield important insight. We also present the first corrections to local virial and pressure fields to account for the constraints typically used in lipid simulations that otherwise cause problems in highly oriented systems such as bilayers. Based on simulations of an asymmetric bacterial ion channel in a POPC bilayer, we demonstrate how 3D-resolved pressure can probe for both short-range and long-range effects from the protein on the membrane environment. We also show how surface tension is a sensitive metric for inter-leaflet equilibrium and can be used to detect even subtle imbalances between bilayer leaflets in a membrane-protein s...







Pediatrician schedule:Bear 18,499
Pediatrician schedule: Brandywine, DE 82,672
Pediatrician schedule: Brookside, DE 15,569
Pediatrician schedule: Central Kent 21,857
Pediatrician schedule: Central Pencader 33,750
Pediatrician schedule: Claymont 9,695
Pediatrician schedule: Dover, DE 36,560
Pediatrician schedule: Edgemoor 6,300
Pediatrician schedule: Glasgow, DE 13,501
Pediatrician schedule: Greater Newark 70,573
Pediatrician schedule: Hockessin 13,567
Pediatrician schedule: Lower Christiana 38,118
Pediatrician schedule: Middletown, DE 12,726
Pediatrician schedule: Milford, DE 8,592
Pediatrician schedule: Newark, DE 30,371
Pediatrician schedule: North Star, DE 8,703
Pediatrician schedule: Piedmont, DE 30,902
Pediatrician schedule: Pike Creek 20,769
Pediatrician schedule: Pike Creek-Central Kirkwood 44,493
Pediatrician schedule: Seaford, DE 7,329
Pediatrician schedule: Smyrna, DE 8,917
Pediatrician schedule: Upper Christiana 25,793
Pediatrician schedule: Wilmington Manor 8,687
Pediatrician schedule: Wilmington, DE 73,069
Pediatrician schedule:Alachua 9,424
Pediatrician schedule: Altamonte Springs 39,942
Pediatrician schedule: Andover, FL 9,221
Pediatrician schedule: Apollo Beach 8,680
Pediatrician schedule: Apopka 38,809
Pediatrician schedule: Arcadia, FL 6,899
Pediatrician schedule: Atlantic Beach, FL 13,169
Pediatrician schedule: Auburndale, FL 13,987
Pediatrician schedule: Aventura 30,333
Pediatrician schedule: Avon Park 8,824
Pediatrician schedule: Azalea Park 13,076
Pediatrician schedule: Baker, FL 7,134
Pediatrician schedule: Bartow, FL 16,959
Pediatrician schedule: Bay Hill 6,113
Pediatrician schedule: Bayonet Point 31,196
Pediatrician schedule: Bayshore Gardens 20,508
Pediatrician schedule: Beacon Square 9,610
Pediatrician schedule: Bee Ridge 9,861
Pediatrician schedule: Bellair-Meadowbrook Terrace 18,423
Pediatrician schedule: Belle Glade 16,604
Pediatrician schedule: Belle Isle 6,553
Pediatrician schedule: Bellview, FL 21,761
Pediatrician schedule: Beverly Hills, FL 9,803
Pediatrician schedule: Bloomingdale, FL 23,134
Pediatrician schedule: Boca Ciega 68,887
Pediatrician schedule: Boca Del Mar 24,318


Eur. J. Lipid Sci. Technol. 1/2013
Hyperresponsiveness of mice deficient in plasma-secreted sphingomyelinase reveals its pivotal role in early phase of host response [Research Articles]
Metabolic products of soluble epoxide hydrolase are essential for monocyte chemotaxis to MCP-1 in vitro and in vivo [Research Articles]
Effects of soluble epoxide hydrolase inhibitor on the expression of fatty acid synthase in peripheral blood mononuclear cell in patients with acute coronary syndrome
Biocatalysis in lipid modification, Greifswald 19–21 September 2012
Ovarian granulosa cells utilize scavenger receptor SR-BI to evade cellular cholesterol homeostatic control for steroid synthesis [Research Articles]
ERRATUM [Errata]
The influence of weight excess on the postprandial lipemia in adolescents
Quantitative fluorescence imaging reveals point of release for lipoproteins during LDLR-dependent uptake [Research Articles]
Mass spectrometry images acylcarnitines, phosphatidylcholines, and sphingomyelin in MDA-MB-231 breast tumor models [Research Articles]

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Risk factors for cardiovascular disease: renewed interest in triglycerides

2013-02-15 22:39:00 (читать в оригинале)

Clinical Lipidology , February 2013, Vol. 8, No. 1, Pages 1-4. (Source: Future Medicine: Clinical Lipidology)







Pediatrician schedule:Bear 18,499
Pediatrician schedule: Brandywine, DE 82,672
Pediatrician schedule: Brookside, DE 15,569
Pediatrician schedule: Central Kent 21,857
Pediatrician schedule: Central Pencader 33,750
Pediatrician schedule: Claymont 9,695
Pediatrician schedule: Dover, DE 36,560
Pediatrician schedule: Edgemoor 6,300
Pediatrician schedule: Glasgow, DE 13,501
Pediatrician schedule: Greater Newark 70,573
Pediatrician schedule: Hockessin 13,567
Pediatrician schedule: Lower Christiana 38,118
Pediatrician schedule: Middletown, DE 12,726
Pediatrician schedule: Milford, DE 8,592
Pediatrician schedule: Newark, DE 30,371
Pediatrician schedule: North Star, DE 8,703
Pediatrician schedule: Piedmont, DE 30,902
Pediatrician schedule: Pike Creek 20,769
Pediatrician schedule: Pike Creek-Central Kirkwood 44,493
Pediatrician schedule: Seaford, DE 7,329
Pediatrician schedule: Smyrna, DE 8,917
Pediatrician schedule: Upper Christiana 25,793
Pediatrician schedule: Wilmington Manor 8,687
Pediatrician schedule: Wilmington, DE 73,069
Pediatrician schedule:Alachua 9,424
Pediatrician schedule: Altamonte Springs 39,942
Pediatrician schedule: Andover, FL 9,221
Pediatrician schedule: Apollo Beach 8,680
Pediatrician schedule: Apopka 38,809
Pediatrician schedule: Arcadia, FL 6,899
Pediatrician schedule: Atlantic Beach, FL 13,169
Pediatrician schedule: Auburndale, FL 13,987
Pediatrician schedule: Aventura 30,333
Pediatrician schedule: Avon Park 8,824
Pediatrician schedule: Azalea Park 13,076
Pediatrician schedule: Baker, FL 7,134
Pediatrician schedule: Bartow, FL 16,959
Pediatrician schedule: Bay Hill 6,113
Pediatrician schedule: Bayonet Point 31,196
Pediatrician schedule: Bayshore Gardens 20,508
Pediatrician schedule: Beacon Square 9,610
Pediatrician schedule: Bee Ridge 9,861
Pediatrician schedule: Bellair-Meadowbrook Terrace 18,423
Pediatrician schedule: Belle Glade 16,604
Pediatrician schedule: Belle Isle 6,553
Pediatrician schedule: Bellview, FL 21,761
Pediatrician schedule: Beverly Hills, FL 9,803
Pediatrician schedule: Bloomingdale, FL 23,134
Pediatrician schedule: Boca Ciega 68,887
Pediatrician schedule: Boca Del Mar 24,318


CD36 homolog divergence is responsible for the selectivity of carotenoid species migration to the silk gland of the silkworm Bombyx mori [Research Articles]
Phenolic acid content and sensory properties of two Spanish monovarietal virgin olive oils
Adipose tissue arachidonic acid content is associated with the expression of 5-lipoxygenase in atherosclerotic plaques
Naringenin prevents cholesterol-induced systemic inflammation, metabolic dysregulation, and atherosclerosis in Ldlr-/- mice [Research Articles]
Ovarian granulosa cells utilize scavenger receptor SR-BI to evade cellular cholesterol homeostatic control for steroid synthesis [Research Articles]
The Influence of The UV Irradiation on Degradation of Virgin Rapeseed Oils Obtained From Different Rape Varieties by Cold Press Method
Mass spectrometry images acylcarnitines, phosphatidylcholines, and sphingomyelin in MDA-MB-231 breast tumor models [Research Articles]
Biocatalysis in lipid modification, Greifswald 19–21 September 2012
The influence of weight excess on the postprandial lipemia in adolescents
The combined effects of genetic variation in the SIRT1 gene and dietary intake of n-3 and n-6 polyunsaturated fatty acids on serum LDL-C and HDL-C levels: a population based study

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Glycemic control low priority in diabetes CVD prevention

2013-02-15 22:39:00 (читать в оригинале)

Maintaining glycemic control does not reduce the likelihood for cardiovascular disease leading to hospitalization in people with Type 2 diabetes, report US researchers. (Source: MedWire News - Lipidology)







Pediatrician schedule:Bear 18,499
Pediatrician schedule: Brandywine, DE 82,672
Pediatrician schedule: Brookside, DE 15,569
Pediatrician schedule: Central Kent 21,857
Pediatrician schedule: Central Pencader 33,750
Pediatrician schedule: Claymont 9,695
Pediatrician schedule: Dover, DE 36,560
Pediatrician schedule: Edgemoor 6,300
Pediatrician schedule: Glasgow, DE 13,501
Pediatrician schedule: Greater Newark 70,573
Pediatrician schedule: Hockessin 13,567
Pediatrician schedule: Lower Christiana 38,118
Pediatrician schedule: Middletown, DE 12,726
Pediatrician schedule: Milford, DE 8,592
Pediatrician schedule: Newark, DE 30,371
Pediatrician schedule: North Star, DE 8,703
Pediatrician schedule: Piedmont, DE 30,902
Pediatrician schedule: Pike Creek 20,769
Pediatrician schedule: Pike Creek-Central Kirkwood 44,493
Pediatrician schedule: Seaford, DE 7,329
Pediatrician schedule: Smyrna, DE 8,917
Pediatrician schedule: Upper Christiana 25,793
Pediatrician schedule: Wilmington Manor 8,687
Pediatrician schedule: Wilmington, DE 73,069
Pediatrician schedule:Alachua 9,424
Pediatrician schedule: Altamonte Springs 39,942
Pediatrician schedule: Andover, FL 9,221
Pediatrician schedule: Apollo Beach 8,680
Pediatrician schedule: Apopka 38,809
Pediatrician schedule: Arcadia, FL 6,899
Pediatrician schedule: Atlantic Beach, FL 13,169
Pediatrician schedule: Auburndale, FL 13,987
Pediatrician schedule: Aventura 30,333
Pediatrician schedule: Avon Park 8,824
Pediatrician schedule: Azalea Park 13,076
Pediatrician schedule: Baker, FL 7,134
Pediatrician schedule: Bartow, FL 16,959
Pediatrician schedule: Bay Hill 6,113
Pediatrician schedule: Bayonet Point 31,196
Pediatrician schedule: Bayshore Gardens 20,508
Pediatrician schedule: Beacon Square 9,610
Pediatrician schedule: Bee Ridge 9,861
Pediatrician schedule: Bellair-Meadowbrook Terrace 18,423
Pediatrician schedule: Belle Glade 16,604
Pediatrician schedule: Belle Isle 6,553
Pediatrician schedule: Bellview, FL 21,761
Pediatrician schedule: Beverly Hills, FL 9,803
Pediatrician schedule: Bloomingdale, FL 23,134
Pediatrician schedule: Boca Ciega 68,887
Pediatrician schedule: Boca Del Mar 24,318


Caspase-1 deficiency in mice reduces intestinal triglyceride absorption and hepatic triglyceride secretion [Research Articles]
Genetic variation at the FADS1-FADS2 gene locus influences delta-5 desaturase activity and LC-PUFA proportions after fish oil supplement [Patient-Oriented and Epidemiological Research]
Lipoprotein metabolism in patients with type 1 diabetes under intensive insulin treatment
Comparative study of high-dose Xuezhikang and low-dose Xuezhikang plus ezetimibe on pro- and anti-inflammatory markers
Eur. J. Lipid Sci. Technol. 1/2013
Hyperresponsiveness of mice deficient in plasma-secreted sphingomyelinase reveals its pivotal role in early phase of host response [Research Articles]
Influence of kernel roasting on bioactive components and oxidative stability of pine nut oil
Assessing Smectic Liquid-Crystal Continuum Models for Elastic Bilayer Deformations.
Phenolic acid content and sensory properties of two Spanish monovarietal virgin olive oils
Altered membrane lipid composition and functional parameters of circulating cells in cockles (Cerastoderma edule) affected by disseminated neoplasia.

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Eur. J. Lipid Sci. Technol. 2/2013

2013-02-15 22:39:00 (читать в оригинале)

(Source: European Journal of Lipid Science and Technology)







Pediatrician schedule:Bear 18,499
Pediatrician schedule: Brandywine, DE 82,672
Pediatrician schedule: Brookside, DE 15,569
Pediatrician schedule: Central Kent 21,857
Pediatrician schedule: Central Pencader 33,750
Pediatrician schedule: Claymont 9,695
Pediatrician schedule: Dover, DE 36,560
Pediatrician schedule: Edgemoor 6,300
Pediatrician schedule: Glasgow, DE 13,501
Pediatrician schedule: Greater Newark 70,573
Pediatrician schedule: Hockessin 13,567
Pediatrician schedule: Lower Christiana 38,118
Pediatrician schedule: Middletown, DE 12,726
Pediatrician schedule: Milford, DE 8,592
Pediatrician schedule: Newark, DE 30,371
Pediatrician schedule: North Star, DE 8,703
Pediatrician schedule: Piedmont, DE 30,902
Pediatrician schedule: Pike Creek 20,769
Pediatrician schedule: Pike Creek-Central Kirkwood 44,493
Pediatrician schedule: Seaford, DE 7,329
Pediatrician schedule: Smyrna, DE 8,917
Pediatrician schedule: Upper Christiana 25,793
Pediatrician schedule: Wilmington Manor 8,687
Pediatrician schedule: Wilmington, DE 73,069
Pediatrician schedule:Alachua 9,424
Pediatrician schedule: Altamonte Springs 39,942
Pediatrician schedule: Andover, FL 9,221
Pediatrician schedule: Apollo Beach 8,680
Pediatrician schedule: Apopka 38,809
Pediatrician schedule: Arcadia, FL 6,899
Pediatrician schedule: Atlantic Beach, FL 13,169
Pediatrician schedule: Auburndale, FL 13,987
Pediatrician schedule: Aventura 30,333
Pediatrician schedule: Avon Park 8,824
Pediatrician schedule: Azalea Park 13,076
Pediatrician schedule: Baker, FL 7,134
Pediatrician schedule: Bartow, FL 16,959
Pediatrician schedule: Bay Hill 6,113
Pediatrician schedule: Bayonet Point 31,196
Pediatrician schedule: Bayshore Gardens 20,508
Pediatrician schedule: Beacon Square 9,610
Pediatrician schedule: Bee Ridge 9,861
Pediatrician schedule: Bellair-Meadowbrook Terrace 18,423
Pediatrician schedule: Belle Glade 16,604
Pediatrician schedule: Belle Isle 6,553
Pediatrician schedule: Bellview, FL 21,761
Pediatrician schedule: Beverly Hills, FL 9,803
Pediatrician schedule: Bloomingdale, FL 23,134
Pediatrician schedule: Boca Ciega 68,887
Pediatrician schedule: Boca Del Mar 24,318


The influence of weight excess on the postprandial lipemia in adolescents
Risk factors for cardiovascular disease: renewed interest in triglycerides
Relevance of minor components stability in commercial olive oil quality during the market period
Biocatalysis in lipid modification, Greifswald 19–21 September 2012
PPAR{gamma} coactivator-1{alpha} contributes to exercise-induced regulation of intramuscular lipid droplet programming in mice and humans [Patient-Oriented and Epidemiological Research]
Fourier transform mid‐infrared spectroscopy evaluation of early stages of virgin olive oil autoxidation
Adipose tissue arachidonic acid content is associated with the expression of 5-lipoxygenase in atherosclerotic plaques
Unique gangliosides synthesized in vitro by sialyltransferases from marine bacteria and their characterization: ganglioside synthesis by bacterial sialyltransferases [Research Articles]
Eur. J. Lipid Sci. Technol. 1/2013
Probing microscopic material properties inside simulated membranes through spatially resolved three-dimensional local pressure fields and surface tensions.

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Dual actions of fibroblast growth factor 19 on lipid metabolism [Research Articles]

2013-02-15 22:39:00 (читать в оригинале)

Elevated triglyceride (TG) and cholesterol levels are risk factors for cardiovascular disease and are often associated with diabetes and metabolic syndrome. Recent reports suggest that fibroblast growth factor (FGF)19 and FGF21 can dramatically improve metabolic dysfunction, including hyperglycemia, hypertriglyceridemia, and hypercholesterolemia. Due to their similar receptor specificities and co-receptor requirements, FGF19 and FGF21 share many common properties and have been thought to be interchangeable in metabolic regulation. Here we directly compared how pharmacological administration of recombinant FGF19 or FGF21 proteins affect metabolism in B6.V-Lepob/J leptin-deficient mice. FGF19 and FGF21 equally improved glucose parameters; however, we observed increased serum TG and cholester...







Pediatrician schedule:Bear 18,499
Pediatrician schedule: Brandywine, DE 82,672
Pediatrician schedule: Brookside, DE 15,569
Pediatrician schedule: Central Kent 21,857
Pediatrician schedule: Central Pencader 33,750
Pediatrician schedule: Claymont 9,695
Pediatrician schedule: Dover, DE 36,560
Pediatrician schedule: Edgemoor 6,300
Pediatrician schedule: Glasgow, DE 13,501
Pediatrician schedule: Greater Newark 70,573
Pediatrician schedule: Hockessin 13,567
Pediatrician schedule: Lower Christiana 38,118
Pediatrician schedule: Middletown, DE 12,726
Pediatrician schedule: Milford, DE 8,592
Pediatrician schedule: Newark, DE 30,371
Pediatrician schedule: North Star, DE 8,703
Pediatrician schedule: Piedmont, DE 30,902
Pediatrician schedule: Pike Creek 20,769
Pediatrician schedule: Pike Creek-Central Kirkwood 44,493
Pediatrician schedule: Seaford, DE 7,329
Pediatrician schedule: Smyrna, DE 8,917
Pediatrician schedule: Upper Christiana 25,793
Pediatrician schedule: Wilmington Manor 8,687
Pediatrician schedule: Wilmington, DE 73,069
Pediatrician schedule:Alachua 9,424
Pediatrician schedule: Altamonte Springs 39,942
Pediatrician schedule: Andover, FL 9,221
Pediatrician schedule: Apollo Beach 8,680
Pediatrician schedule: Apopka 38,809
Pediatrician schedule: Arcadia, FL 6,899
Pediatrician schedule: Atlantic Beach, FL 13,169
Pediatrician schedule: Auburndale, FL 13,987
Pediatrician schedule: Aventura 30,333
Pediatrician schedule: Avon Park 8,824
Pediatrician schedule: Azalea Park 13,076
Pediatrician schedule: Baker, FL 7,134
Pediatrician schedule: Bartow, FL 16,959
Pediatrician schedule: Bay Hill 6,113
Pediatrician schedule: Bayonet Point 31,196
Pediatrician schedule: Bayshore Gardens 20,508
Pediatrician schedule: Beacon Square 9,610
Pediatrician schedule: Bee Ridge 9,861
Pediatrician schedule: Bellair-Meadowbrook Terrace 18,423
Pediatrician schedule: Belle Glade 16,604
Pediatrician schedule: Belle Isle 6,553
Pediatrician schedule: Bellview, FL 21,761
Pediatrician schedule: Beverly Hills, FL 9,803
Pediatrician schedule: Bloomingdale, FL 23,134
Pediatrician schedule: Boca Ciega 68,887
Pediatrician schedule: Boca Del Mar 24,318


Comparison of the pharmacological profiles of murine antisense oligonucleotides targeting apolipoprotein B and microsomal triglyceride transfer protein [Research Articles]
Cobalt carbonyl complexes as probes for alkyne-tagged lipids [Methods]
ERRATUM [Errata]
Lipid–Protein Interactions in Membranes: implications for health and disease
Metabolic products of soluble epoxide hydrolase are essential for monocyte chemotaxis to MCP-1 in vitro and in vivo [Research Articles]
Phenolic acid content and sensory properties of two Spanish monovarietal virgin olive oils
Assessing Smectic Liquid-Crystal Continuum Models for Elastic Bilayer Deformations.
Hyperresponsiveness of mice deficient in plasma-secreted sphingomyelinase reveals its pivotal role in early phase of host response [Research Articles]
Biocatalysis in lipid modification, Greifswald 19–21 September 2012
Adipose tissue arachidonic acid content is associated with the expression of 5-lipoxygenase in atherosclerotic plaques