pd5| Голосов: 1 Адрес блога: http://americanpediatrics.blogspot.com/ Добавлен: 2013-02-15 16:46:23 блограйдером 1234zz

Melanocortin 4 receptor agonists activate obesity-related hypertension

2013-02-15 16:49:00 (читать в оригинале)

A cellular correlation between melanocortin 4 receptor agonists and their role in obesity-associated hypertension has been identified, according to data published in Cell.“Obesity is a major risk factor for cardiovascular disease, with recent statistics showing that obese adults are three to four times more likely to develop high blood pressure,” study researcher Nina Balthasar, PhD, from the school of physiology and pharmacology at the University of Bristol, United Kingdom, said in a press release. “In order to curb the escalating incidence of obesity and obesity-related diseases, a primary prevention goal must be to understand the physiological processes underlying our vulnerability to weight gain — knowledge that is central to the development of novel, effective therapies.”







pediatrician schedule: Anchorage, AK 286,174
pediatrician schedule: Bethel, AK 6,522
pediatrician schedule: College 13,493
pediatrician schedule: Fairbanks, AK 35,252
pediatrician schedule: Juneau, AK 30,796
pediatrician schedule: Kalifornsky 6,268
pediatrician schedule: Kenai 7,945
pediatrician schedule: Ketchikan 7,515
pediatrician schedule: Knik-Fairview 7,049
pediatrician schedule: Kodiak 6,357
pediatrician schedule: Lakes 6,706
pediatrician schedule: Meadow Lakes 6,635
pediatrician schedule: Palmer, AK 8,428
pediatrician schedule: Sitka 8,747
pediatrician schedule: Tanaina 6,874
pediatrician schedule: Wasilla 10,692
pediatrician schedule: Apache Junction 34,284
pediatrician schedule: Apache, AZ 11,958
pediatrician schedule: Arivaca 59,243
pediatrician schedule: Arizona City 7,320
pediatrician schedule: Avondale, AZ 84,914
pediatrician schedule: Big Park 6,584
pediatrician schedule: Buckeye 8,173
pediatrician schedule: Bullhead City 40,747
pediatrician schedule: Camp Verde 10,871
pediatrician schedule: Casa Grande 43,878
pediatrician schedule: Casas Adobes 63,436
pediatrician schedule: Catalina 8,250
pediatrician schedule: Catalina Foothills 63,181
pediatrician schedule: Chandler, AZ 255,230
pediatrician schedule: Chino Valley 11,182
pediatrician schedule: Coconino 81,338
pediatrician schedule: Coolidge, AZ 11,079
pediatrician schedule: Cottonwood, AZ 11,361
pediatrician schedule: Cottonwood-Verde Village 13,266
pediatrician schedule: Deer Valley, AZ 186,030
pediatrician schedule: Dewey-Humboldt 7,393
pediatrician schedule: Douglas, AZ 15,489
pediatrician schedule: Drexel Heights 28,010
pediatrician schedule: El Mirage 9,514

Monitoring cholesterol, other parameters urged for children with HIV
Inflammatory marker IL-6 indicates disease severity, predicts treatment failure in ulcerative colitis
Patients with hypertension increase physical activity, reduce blood pressure levels after TKA
Active lifestyle appears as beneficial as structured exercise
Vitamin D deficiency linked to ulcerative colitis activity

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Denosumab reduced wrist fracture in postmenopausal women with osteoporosis

2013-02-15 16:49:00 (читать в оригинале)

Upon further analysis of data from the FREEDOM trial, researchers confirmed that denosumab significantly improved radius bone mineral density, mass and strength compared with placebo, besides significantly reducing the risk for wrist fracture.Researcher James A. Simon, MD, CCD, NCMP, FACOG, of George Washington University, and colleagues determined the effects of denosumab (Prolia, Xgeva; Amgen) on radius cortical and trabecular bone density, mass, strength and wrist fracture incidence from the study in which postmenopausal women with osteoporosis (n=7,808) received placebo or denosumab 60 mg every 6 months for 36 months.







pediatrician schedule: Anchorage, AK 286,174
pediatrician schedule: Bethel, AK 6,522
pediatrician schedule: College 13,493
pediatrician schedule: Fairbanks, AK 35,252
pediatrician schedule: Juneau, AK 30,796
pediatrician schedule: Kalifornsky 6,268
pediatrician schedule: Kenai 7,945
pediatrician schedule: Ketchikan 7,515
pediatrician schedule: Knik-Fairview 7,049
pediatrician schedule: Kodiak 6,357
pediatrician schedule: Lakes 6,706
pediatrician schedule: Meadow Lakes 6,635
pediatrician schedule: Palmer, AK 8,428
pediatrician schedule: Sitka 8,747
pediatrician schedule: Tanaina 6,874
pediatrician schedule: Wasilla 10,692
pediatrician schedule: Apache Junction 34,284
pediatrician schedule: Apache, AZ 11,958
pediatrician schedule: Arivaca 59,243
pediatrician schedule: Arizona City 7,320
pediatrician schedule: Avondale, AZ 84,914
pediatrician schedule: Big Park 6,584
pediatrician schedule: Buckeye 8,173
pediatrician schedule: Bullhead City 40,747
pediatrician schedule: Camp Verde 10,871
pediatrician schedule: Casa Grande 43,878
pediatrician schedule: Casas Adobes 63,436
pediatrician schedule: Catalina 8,250
pediatrician schedule: Catalina Foothills 63,181
pediatrician schedule: Chandler, AZ 255,230
pediatrician schedule: Chino Valley 11,182
pediatrician schedule: Coconino 81,338
pediatrician schedule: Coolidge, AZ 11,079
pediatrician schedule: Cottonwood, AZ 11,361
pediatrician schedule: Cottonwood-Verde Village 13,266
pediatrician schedule: Deer Valley, AZ 186,030
pediatrician schedule: Dewey-Humboldt 7,393
pediatrician schedule: Douglas, AZ 15,489
pediatrician schedule: Drexel Heights 28,010
pediatrician schedule: El Mirage 9,514

Inflammatory marker IL-6 indicates disease severity, predicts treatment failure in ulcerative colitis
Vitamin D deficiency linked to ulcerative colitis activity
Melanocortin 4 receptor agonists activate obesity-related hypertension
Patients with hypertension increase physical activity, reduce blood pressure levels after TKA
Monitoring cholesterol, other parameters urged for children with HIV

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Pioglitazone approved by FDA for abbreviated new drug application

2013-02-15 16:49:00 (читать в оригинале)

The FDA announced it has approved the abbreviated new drug application for pioglitazone, indicated for the treatment of type 2 diabetes in addition to diet and exercise.According to a press release, the thiazolidinedione has been given full approval for the application currently manufactured and supplied by Synthon Pharmaceuticals, Inc. and Breckenridge Pharmaceutical, Inc. It will be available in 15-mg, 30-mg, and 45-mg doses.







pediatrician schedule: Anchorage, AK 286,174
pediatrician schedule: Bethel, AK 6,522
pediatrician schedule: College 13,493
pediatrician schedule: Fairbanks, AK 35,252
pediatrician schedule: Juneau, AK 30,796
pediatrician schedule: Kalifornsky 6,268
pediatrician schedule: Kenai 7,945
pediatrician schedule: Ketchikan 7,515
pediatrician schedule: Knik-Fairview 7,049
pediatrician schedule: Kodiak 6,357
pediatrician schedule: Lakes 6,706
pediatrician schedule: Meadow Lakes 6,635
pediatrician schedule: Palmer, AK 8,428
pediatrician schedule: Sitka 8,747
pediatrician schedule: Tanaina 6,874
pediatrician schedule: Wasilla 10,692
pediatrician schedule: Apache Junction 34,284
pediatrician schedule: Apache, AZ 11,958
pediatrician schedule: Arivaca 59,243
pediatrician schedule: Arizona City 7,320
pediatrician schedule: Avondale, AZ 84,914
pediatrician schedule: Big Park 6,584
pediatrician schedule: Buckeye 8,173
pediatrician schedule: Bullhead City 40,747
pediatrician schedule: Camp Verde 10,871
pediatrician schedule: Casa Grande 43,878
pediatrician schedule: Casas Adobes 63,436
pediatrician schedule: Catalina 8,250
pediatrician schedule: Catalina Foothills 63,181
pediatrician schedule: Chandler, AZ 255,230
pediatrician schedule: Chino Valley 11,182
pediatrician schedule: Coconino 81,338
pediatrician schedule: Coolidge, AZ 11,079
pediatrician schedule: Cottonwood, AZ 11,361
pediatrician schedule: Cottonwood-Verde Village 13,266
pediatrician schedule: Deer Valley, AZ 186,030
pediatrician schedule: Dewey-Humboldt 7,393
pediatrician schedule: Douglas, AZ 15,489
pediatrician schedule: Drexel Heights 28,010
pediatrician schedule: El Mirage 9,514

Patients with hypertension increase physical activity, reduce blood pressure levels after TKA
Monitoring cholesterol, other parameters urged for children with HIV
Denosumab reduced wrist fracture in postmenopausal women with osteoporosis
Melanocortin 4 receptor agonists activate obesity-related hypertension
Vitamin D deficiency linked to ulcerative colitis activity

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Vitamin A deficiency reduced response to therapy for chronic HCV

2013-02-15 16:49:00 (читать в оригинале)

Vitamin A deficiency is common among patients with chronic hepatitis C, and is associated with nonresponse to interferon-based treatment, according to recent results.Researchers measured vitamin A and 25-OH vitamin D levels in 199 treatment-naive patients with chronic HCV before receiving interferon (INF)-based treatment, and compared them with 119 healthy controls. Participants also underwent genotyping for the IL-28B rs12979860 C>T polymorphism.







pediatrician schedule: Anchorage, AK 286,174
pediatrician schedule: Bethel, AK 6,522
pediatrician schedule: College 13,493
pediatrician schedule: Fairbanks, AK 35,252
pediatrician schedule: Juneau, AK 30,796
pediatrician schedule: Kalifornsky 6,268
pediatrician schedule: Kenai 7,945
pediatrician schedule: Ketchikan 7,515
pediatrician schedule: Knik-Fairview 7,049
pediatrician schedule: Kodiak 6,357
pediatrician schedule: Lakes 6,706
pediatrician schedule: Meadow Lakes 6,635
pediatrician schedule: Palmer, AK 8,428
pediatrician schedule: Sitka 8,747
pediatrician schedule: Tanaina 6,874
pediatrician schedule: Wasilla 10,692
pediatrician schedule: Apache Junction 34,284
pediatrician schedule: Apache, AZ 11,958
pediatrician schedule: Arivaca 59,243
pediatrician schedule: Arizona City 7,320
pediatrician schedule: Avondale, AZ 84,914
pediatrician schedule: Big Park 6,584
pediatrician schedule: Buckeye 8,173
pediatrician schedule: Bullhead City 40,747
pediatrician schedule: Camp Verde 10,871
pediatrician schedule: Casa Grande 43,878
pediatrician schedule: Casas Adobes 63,436
pediatrician schedule: Catalina 8,250
pediatrician schedule: Catalina Foothills 63,181
pediatrician schedule: Chandler, AZ 255,230
pediatrician schedule: Chino Valley 11,182
pediatrician schedule: Coconino 81,338
pediatrician schedule: Coolidge, AZ 11,079
pediatrician schedule: Cottonwood, AZ 11,361
pediatrician schedule: Cottonwood-Verde Village 13,266
pediatrician schedule: Deer Valley, AZ 186,030
pediatrician schedule: Dewey-Humboldt 7,393
pediatrician schedule: Douglas, AZ 15,489
pediatrician schedule: Drexel Heights 28,010
pediatrician schedule: El Mirage 9,514

Pioglitazone approved by FDA for abbreviated new drug application
Vitamin D deficiency linked to ulcerative colitis activity
Inflammatory marker IL-6 indicates disease severity, predicts treatment failure in ulcerative colitis
Melanocortin 4 receptor agonists activate obesity-related hypertension
Monitoring cholesterol, other parameters urged for children with HIV

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FDA: More CV data needed on Tresiba, Ryzodeg before approval

2013-02-15 16:49:00 (читать в оригинале)

The FDA has denied approvals for two potential insulin therapies in the pipeline due to a lack of cardiovascular data, according to a press release. In a letter from the FDA to the manufacturer, the agency wrote that insulin degludec/insulin aspart (Ryzodeg, Novo Nordisk) and insulin degludec (Tresiba, Novo Nordisk) require additional cardiovascular data from an outcomes trial before they will complete the new drug application. The medications are currently approved in the European Union, Japan and Mexico.







pediatrician schedule: Anchorage, AK 286,174
pediatrician schedule: Bethel, AK 6,522
pediatrician schedule: College 13,493
pediatrician schedule: Fairbanks, AK 35,252
pediatrician schedule: Juneau, AK 30,796
pediatrician schedule: Kalifornsky 6,268
pediatrician schedule: Kenai 7,945
pediatrician schedule: Ketchikan 7,515
pediatrician schedule: Knik-Fairview 7,049
pediatrician schedule: Kodiak 6,357
pediatrician schedule: Lakes 6,706
pediatrician schedule: Meadow Lakes 6,635
pediatrician schedule: Palmer, AK 8,428
pediatrician schedule: Sitka 8,747
pediatrician schedule: Tanaina 6,874
pediatrician schedule: Wasilla 10,692
pediatrician schedule: Apache Junction 34,284
pediatrician schedule: Apache, AZ 11,958
pediatrician schedule: Arivaca 59,243
pediatrician schedule: Arizona City 7,320
pediatrician schedule: Avondale, AZ 84,914
pediatrician schedule: Big Park 6,584
pediatrician schedule: Buckeye 8,173
pediatrician schedule: Bullhead City 40,747
pediatrician schedule: Camp Verde 10,871
pediatrician schedule: Casa Grande 43,878
pediatrician schedule: Casas Adobes 63,436
pediatrician schedule: Catalina 8,250
pediatrician schedule: Catalina Foothills 63,181
pediatrician schedule: Chandler, AZ 255,230
pediatrician schedule: Chino Valley 11,182
pediatrician schedule: Coconino 81,338
pediatrician schedule: Coolidge, AZ 11,079
pediatrician schedule: Cottonwood, AZ 11,361
pediatrician schedule: Cottonwood-Verde Village 13,266
pediatrician schedule: Deer Valley, AZ 186,030
pediatrician schedule: Dewey-Humboldt 7,393
pediatrician schedule: Douglas, AZ 15,489
pediatrician schedule: Drexel Heights 28,010
pediatrician schedule: El Mirage 9,514

Pioglitazone approved by FDA for abbreviated new drug application
Vitamin D deficiency linked to ulcerative colitis activity
Active lifestyle appears as beneficial as structured exercise
Denosumab reduced wrist fracture in postmenopausal women with osteoporosis
Vitamin A deficiency reduced response to therapy for chronic HCV